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Though the opiate receptor relies on G protein coupling for signal transduction, this receptor was uncovered to make use of arrestin activation for internalization on the receptor. Normally, the receptor promoted no other signaling cascades (fifty nine) Modifications of conolidine have resulted

Excellent improvement plans to improve therapy of acute suffering and cancer discomfort should contain five important factors: guaranteeing that a report of unrelieved soreness raises a "red flag" that pulls clinicians' attention, and coordinating and assessing implementation of su

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